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Acid Relux (GERD) and Protein Deficiency

Gastroesophageal Reflux Disorder (GERD) proteins, it will be doubly compromised .
is classified as a Functional GI Some studies show that regulating
Disorder, in which stomach acid (HCL) serotonin through the use of drugs such
backs up (refluxes) into the esophagus. as SSRIs helps calm some of the symptoms
This is due to an imbalance in the of GERD. Let's take a look at the
neuroendocrine system, which causes both biosynthesis of serotoninThe essential
a loss of contractile ability in the amino acid tryptophan is the necessary
esophagus and its openings in the stomach precursor to serotonin and is found in
and diaphragm, as well as an foods like turkey, milk, eggs and
overproduction of HCL (hyperchlorhydria) bananas. Meat also contains tryptophan
and unbalanced secretions of the hormone but it not the best source because it
serotonin. This imbalance leads to also contains significant amounts of the
irritation of the esophageal tissue and a five other amino acids that compete with
decrease in motility and tone of the tryptophan for receptor access. Research
entire esophagus and its opening in the has found the biggest rise in serotonin
diaphragm.The cause for this unbalanced levels to occur after high carbohydrate
neuroendecrine system could well be meals when the release of insulin
lesions in the spinal disks. Studies have encourages certain essential amino acids
shown intervertebral disk lesions to to leave the blood stream and enter the
negatively affect the nervous system1. organ tissues, leaving tryptophan free
In the early 1980s, using specially use albumin transportation to the brain
designed BEV and CCT tests, Dr. Brice without competition. Once tryptophan is
Vickery found that 100% of his GERD absorbed into the blood stream, the blood
patients also had dorsal disk lesions, protein albumin carries it to the cell
very often with no back pain symptoms. where the enzyme tryptophan hydroxylase
Instead, their symptoms included stomach catalyzes the reaction, which creates
and esophageal inflammation along with 5HTP. Then the enzyme dopa decarboxolase
weakness in both the esophageal/stomach catalyzes the change, which produces the
valve and the diaphragm and its opening hormone 5HT, or serotonin. Let's take a
for the esophagus. This weakness can lead look at the proteins involved in this
to the stomach pushing up through the transformation4:
diaphragm in the condition known as First the amino acid typtophan must be
hiatal hernia. The nervous system is broken out of the food and absorbed
closely linked to the endocrine system, Production of the blood protein albumin
and so this system that secretes requires seven of the eleven EAAS.
chemicals such as HCL or serotonin could Trytophan Hydroxylase - 74 AA 41
also be affected by any changes that EAA (16% of the EAA being lysine)
occur due to disk lesions.It is common Dopa Decarboxolase - 480 AA
knowledge that amino acid deficiency does 237 EAA ( 9% of the EAA being leucine)
affect the body's ability to make Serotonin - 428 AA
protein. If even one essential amino acid 236 EAA (85 of the EAA being leucine)If
is missing from the diet, the body can we cannot fully digest the turkey or eggs
not make allt he proteins it needs on a we have eaten we will not get adequate
daily basis. It could well follow that amounts of tryptophan..Incomplete
one cause of GERDs is a general digestion will lead to inadequate amounts
deficiency in amino acids (the building of albumin and catalytic enzymes, not to
blocks of protein), resulting in a mention the final product serotonin. If
deficiency in the spinal disks, the our neuroendocrine system is not working
neuroendocrine system and even the make properly because of degraded spinal
up of the proteins involved in the disks, the expression of these enzymes
production of stomach acid and serotonin. and proteins will be out of balance as
It is interesting to note that Dr. well. In some advanced cases of GERD the
Vickery also found once he cured his system is so unbalanced that the
GERDs patients of protein deficiency, esophageal tissue is damaged resulting in
their symptoms disappeared.Systemic the condition known as esophagitis, these
protein is made up of essential (EAA) and patients are thought to have low albumin
non essential amino acids. EAAs can only levels5)10%- 20% of GERD patients have
be obtained if dietary protein is fully the precancerous condition known as
digested . Dr. Vickery also found that 9 Barrett's Esophagus. In this condition
out of 10 of his patients did not fully the tissue of the esophagus undergoes a
digest their food. A lack of essential change and though there may be no
amino acids leads to an insufficiency in symptoms, it can result in a deadly form
about 3000 enzymes, which cannot be of cancer. These patients show a decrease
synthesized without these amino acids . in the enzyme glutathione transferase6.
Enzymes play a big part in the secretion This enzyme detoxifies carcinogens,
of HCL and serotonin. Hypochlorhydria drugs, environmental toxins, and
(too little stomach acid) and oxidative stress through conjugation with
hyperclorhydria could both be caused by the protein glutathione.Glutathione
the inability to digest and transform Transferase - 218 AA 129 EAA (23%
dietary protein into systemic of EAA being leucine)The essential amino
proteins.The essential amino acids must acid cysteine is the limiting amino acid
be present in the body or malfunctions in the synthesis of glutathione. (This
will occur in the system2. If we cannot means that all the other amino acids in
digest our food into these essential glutathione are limited in their
amino acids, then we cannot make systemic efficiency without adequate levels of
proteins. GERD could be just another cysteine7.)Each systemic protein broken
symptom in a large list of protein down in this article ranges from 40%-55%
deficiency caused diseases and EAAs. The only place we can get these AAs
infections.If people, because of diet, from is the complete digestion of our
aging, environmental factors and stress food. Without them we will become protein
are unable to produce sufficient enzymes deficient. For instance, studies show
to digest their food properly, then that depriving mice of cysteine in their
regular maintenance processes such as diets leads to lower levels of
upkeep and repair of the spinal disk glutathione in their systems and a
material will be compromised due to a decreased ability to handle oxidative
lack of the systemic protein needed to stress8. The body has a number of
keep the disks strong and flexible. As proteins and enzymes that are designed to
lesions begin to appear, the nervous help clear the toxic burden of oxidative
system becomes affected and then the stress from the body. If the body cannot
neuroendocrine system. Stomach motility make a sufficient number of these
and secretions could very well be proteins to handle the stress load, the
affected.Two focal points of GERD system will begin to experience the
research in medical science are HCL effects of this malfunction.If we cannot
production by the stomach cells and the make the proteins we need for our stomach
effects of serotonin on GERD symptoms. to work properly we will begin to
Let's take a look at these chemicals and experience the effects of a
the proteins that are involved in their malfunctioning system.Studies show that a
production HCL secretion in the stomach protein deficient system leads to
is dependent on an active transport malfunctions of the system and illness.
system that is made up of proteins. A The beginning of this breakdown may begin
large portion of those proteins are in the dorsal spinal disks, affecting the
essential amino acids:HCL nervous system and, in the GERDs patient,
The stomach lining contains certain the nueroendocrine system of the
cells called parietal cells, which are stomach..If we are not digesting our
specifically oriented with one surface dietary protein properly we are becoming
facing blood in capillaries and the other increasingly protein deficient and
facing the stomach cavity, where the protein deficiency leads to systemic
active transport of HCL into the stomach malfunction.For more information on
occurs. These cells are sealed together essential amino acids and protein
with tight junction proteins that create deficiencies visit Micheal Furman MD,
an impermeable gasket between the blood "Spinal Stenosis and Neurogenic
and the stomach. Carbon dioxide diffuses Claudication." E-Medicine, July 21,
freely into the cell where it joins with 2004.2. Tracy G. Anthony, Ali K. Reiter,
water. The enzyme carbonic anhydrase,(a Joshua C. Anthony, Scot R. Kimball, and
systemic protein), catalyzes the reaction Leonard S. Jefferson, " Deficiency of
between these two elements, yielding dietary EAA preferentially inhibits mRNA
hydrogen. Chloride ions enter the cell in translation of ribosomal proteins in
a process of ion exchange and on the liver of meal-fed rats." Am J Physiol
stomach side of the cell another large Endocrinol Metab 281: E430-E439, 2001;
protein, H+/K+ Atpase, starts the active 0193-1849/01, Vol. 281, Issue 3,
transport "pump" for HCL production. Free E430-E439, September 20013. Junction
energy (ATP) hydrolyzed by H+/K+ Atpase Adhesion Molecule 1: Q9Y624, NiceProt
pumps out hydrogen (H+) and takes up View of Swiss-Prot, Uni-Prot Carbonic
potassium (K+). K+ flows into the stomach Anhydrase 1:P00915, Bioinformatic
by diffusion through a K+ channel protein Harvester, Stanford University. Potassium
while chloride (CL-) flows into the Voltage Gated Channel: KCNQ1,
stomach through a Cl- channel protein. Bioinformatic harvester, Stanford
This mixture creates a Ph of about .08 in University Gastric H+/K+ ATPase: P20648,
the stomach, which is optimal for food Bioinformatic Harvester, Stanford
digestion. How much of each protein is University4. Tryptophan
EAAs ?: Hydroxylase:Q86WC5 (fragment),
Tight junction protein - 299 total AA Bioinformatic Harvester, Stanford
151 EAA ( 18% of the EAA being valine) University Dopa Decarboxolase5. Andrew S.
Carbonic Anhydrase - 260 total AA Chu, MD, "Esophagitis" E-Medicine, Nov.
106 EAA (17 % of the EAA being leucine) 19, 20046. Brabender J, Lord RV,
K+ channel protein - 392 total AA Wickramasinghe K, Metzger R, Schneider
192 EAA ( 16% of the EAA being leucine) PM, Park JM, Holscher AH, DeMeester TR,
H+/K+ Atpase - 1034 total AA Danenberg KD, Danenberg PV., "Glutathione
500 EAA ( 10% of the EAA being S-transferase-pi expression is
leucine)3Why is there an overproduction downregulated in patients with Barrett's
of acid in the GERD patient? If the esophagus and esophageal adenocarcinoma."
proper essential amino acids must be Journal of Gastrointestal Surgery. 2002
present for the proper function of May-Jun;6(3):359-67.7. Bounous,J, "Whey
proteins, what happens if EAAs are protein concentrate (WPC) and glutathione
missing? Perhaps then the protein modulation in cancer treatment.",
mechanism that makes the HCL for our Anticancer Res. 2000
stomach malfunctions. How do we get these Nov-Dec;20(6C):4785-92.8. Wang ST, Chen
EAAS? By digesting our food HW, Sheen LY, Lii CK., "Methionine and
fully.Serotonin cysteine affect glutathione level,
Science is also looking into the role glutathione-related enzyme activities and
that the hormone seratonin (5HT) plays in the expression of glutathione
GERD because serotonin mediates the S-transferase isozymes in rat
chemical transfer of information between hepatocytes." Journal of Nutrition, 1997
the brain and gut. It does this via the Nov;127(11):2135-41.Eve Pekkala is a
central nervous system. If the nervous technical writer for Supernutrient
system has been compromised due to Company. She has a BA in history and has
breakdown of the spinal disks, then studied exercise science at the
messages given to the secretory system University of South Carolina. She has
will also be compromised. If the system been involved in technical writing for
does not have adequate amounts of amino various bodywork and nutritional
acids available to build secretory businesses since 1995.




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