| Gastroesophageal Reflux Disorder (GERD)
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| | proteins, it will be doubly compromised .
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| is classified as a Functional GI
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| | Some studies show that regulating
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| Disorder, in which stomach acid (HCL)
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| | serotonin through the use of drugs such
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| backs up (refluxes) into the esophagus.
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| | as SSRIs helps calm some of the symptoms
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| This is due to an imbalance in the
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| | of GERD. Let's take a look at the
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| neuroendocrine system, which causes both
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| | biosynthesis of serotoninThe essential
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| a loss of contractile ability in the
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| | amino acid tryptophan is the necessary
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| esophagus and its openings in the stomach
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| | precursor to serotonin and is found in
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| and diaphragm, as well as an
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| | foods like turkey, milk, eggs and
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| overproduction of HCL (hyperchlorhydria)
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| | bananas. Meat also contains tryptophan
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| and unbalanced secretions of the hormone
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| | but it not the best source because it
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| serotonin. This imbalance leads to
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| | also contains significant amounts of the
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| irritation of the esophageal tissue and a
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| | five other amino acids that compete with
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| decrease in motility and tone of the
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| | tryptophan for receptor access. Research
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| entire esophagus and its opening in the
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| | has found the biggest rise in serotonin
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| diaphragm.The cause for this unbalanced
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| | levels to occur after high carbohydrate
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| neuroendecrine system could well be
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| | meals when the release of insulin
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| lesions in the spinal disks. Studies have
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| | encourages certain essential amino acids
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| shown intervertebral disk lesions to
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| | to leave the blood stream and enter the
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| negatively affect the nervous system1.
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| | organ tissues, leaving tryptophan free
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| In the early 1980s, using specially
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| | use albumin transportation to the brain
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| designed BEV and CCT tests, Dr. Brice
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| | without competition. Once tryptophan is
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| Vickery found that 100% of his GERD
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| | absorbed into the blood stream, the blood
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| patients also had dorsal disk lesions,
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| | protein albumin carries it to the cell
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| very often with no back pain symptoms.
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| | where the enzyme tryptophan hydroxylase
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| Instead, their symptoms included stomach
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| | catalyzes the reaction, which creates
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| and esophageal inflammation along with
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| | 5HTP. Then the enzyme dopa decarboxolase
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| weakness in both the esophageal/stomach
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| | catalyzes the change, which produces the
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| valve and the diaphragm and its opening
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| | hormone 5HT, or serotonin. Let's take a
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| for the esophagus. This weakness can lead
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| | look at the proteins involved in this
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| to the stomach pushing up through the
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| | transformation4:
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| diaphragm in the condition known as
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| | First the amino acid typtophan must be
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| hiatal hernia. The nervous system is
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| | broken out of the food and absorbed
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| closely linked to the endocrine system,
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| | Production of the blood protein albumin
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| and so this system that secretes
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| | requires seven of the eleven EAAS.
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| chemicals such as HCL or serotonin could
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| | Trytophan Hydroxylase - 74 AA 41
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| also be affected by any changes that
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| | EAA (16% of the EAA being lysine)
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| occur due to disk lesions.It is common
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| | Dopa Decarboxolase - 480 AA
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| knowledge that amino acid deficiency does
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| | 237 EAA ( 9% of the EAA being leucine)
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| affect the body's ability to make
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| | Serotonin - 428 AA
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| protein. If even one essential amino acid
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| | 236 EAA (85 of the EAA being leucine)If
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| is missing from the diet, the body can
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| | we cannot fully digest the turkey or eggs
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| not make allt he proteins it needs on a
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| | we have eaten we will not get adequate
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| daily basis. It could well follow that
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| | amounts of tryptophan..Incomplete
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| one cause of GERDs is a general
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| | digestion will lead to inadequate amounts
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| deficiency in amino acids (the building
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| | of albumin and catalytic enzymes, not to
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| blocks of protein), resulting in a
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| | mention the final product serotonin. If
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| deficiency in the spinal disks, the
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| | our neuroendocrine system is not working
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| neuroendocrine system and even the make
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| | properly because of degraded spinal
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| up of the proteins involved in the
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| | disks, the expression of these enzymes
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| production of stomach acid and serotonin.
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| | and proteins will be out of balance as
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| It is interesting to note that Dr.
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| | well. In some advanced cases of GERD the
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| Vickery also found once he cured his
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| | system is so unbalanced that the
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| GERDs patients of protein deficiency,
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| | esophageal tissue is damaged resulting in
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| their symptoms disappeared.Systemic
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| | the condition known as esophagitis, these
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| protein is made up of essential (EAA) and
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| | patients are thought to have low albumin
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| non essential amino acids. EAAs can only
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| | levels5)10%- 20% of GERD patients have
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| be obtained if dietary protein is fully
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| | the precancerous condition known as
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| digested . Dr. Vickery also found that 9
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| | Barrett's Esophagus. In this condition
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| out of 10 of his patients did not fully
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| | the tissue of the esophagus undergoes a
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| digest their food. A lack of essential
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| | change and though there may be no
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| amino acids leads to an insufficiency in
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| | symptoms, it can result in a deadly form
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| about 3000 enzymes, which cannot be
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| | of cancer. These patients show a decrease
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| synthesized without these amino acids .
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| | in the enzyme glutathione transferase6.
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| Enzymes play a big part in the secretion
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| | This enzyme detoxifies carcinogens,
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| of HCL and serotonin. Hypochlorhydria
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| | drugs, environmental toxins, and
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| (too little stomach acid) and
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| | oxidative stress through conjugation with
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| hyperclorhydria could both be caused by
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| | the protein glutathione.Glutathione
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| the inability to digest and transform
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| | Transferase - 218 AA 129 EAA (23%
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| dietary protein into systemic
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| | of EAA being leucine)The essential amino
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| proteins.The essential amino acids must
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| | acid cysteine is the limiting amino acid
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| be present in the body or malfunctions
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| | in the synthesis of glutathione. (This
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| will occur in the system2. If we cannot
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| | means that all the other amino acids in
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| digest our food into these essential
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| | glutathione are limited in their
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| amino acids, then we cannot make systemic
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| | efficiency without adequate levels of
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| proteins. GERD could be just another
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| | cysteine7.)Each systemic protein broken
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| symptom in a large list of protein
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| | down in this article ranges from 40%-55%
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| deficiency caused diseases and
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| | EAAs. The only place we can get these AAs
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| infections.If people, because of diet,
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| | from is the complete digestion of our
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| aging, environmental factors and stress
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| | food. Without them we will become protein
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| are unable to produce sufficient enzymes
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| | deficient. For instance, studies show
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| to digest their food properly, then
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| | that depriving mice of cysteine in their
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| regular maintenance processes such as
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| | diets leads to lower levels of
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| upkeep and repair of the spinal disk
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| | glutathione in their systems and a
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| material will be compromised due to a
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| | decreased ability to handle oxidative
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| lack of the systemic protein needed to
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| | stress8. The body has a number of
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| keep the disks strong and flexible. As
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| | proteins and enzymes that are designed to
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| lesions begin to appear, the nervous
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| | help clear the toxic burden of oxidative
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| system becomes affected and then the
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| | stress from the body. If the body cannot
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| neuroendocrine system. Stomach motility
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| | make a sufficient number of these
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| and secretions could very well be
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| | proteins to handle the stress load, the
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| affected.Two focal points of GERD
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| | system will begin to experience the
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| research in medical science are HCL
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| | effects of this malfunction.If we cannot
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| production by the stomach cells and the
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| | make the proteins we need for our stomach
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| effects of serotonin on GERD symptoms.
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| | to work properly we will begin to
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| Let's take a look at these chemicals and
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| | experience the effects of a
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| the proteins that are involved in their
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| | malfunctioning system.Studies show that a
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| production HCL secretion in the stomach
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| | protein deficient system leads to
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| is dependent on an active transport
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| | malfunctions of the system and illness.
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| system that is made up of proteins. A
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| | The beginning of this breakdown may begin
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| large portion of those proteins are
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| | in the dorsal spinal disks, affecting the
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| essential amino acids:HCL
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| | nervous system and, in the GERDs patient,
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| The stomach lining contains certain
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| | the nueroendocrine system of the
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| cells called parietal cells, which are
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| | stomach..If we are not digesting our
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| specifically oriented with one surface
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| | dietary protein properly we are becoming
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| facing blood in capillaries and the other
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| | increasingly protein deficient and
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| facing the stomach cavity, where the
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| | protein deficiency leads to systemic
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| active transport of HCL into the stomach
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| | malfunction.For more information on
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| occurs. These cells are sealed together
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| | essential amino acids and protein
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| with tight junction proteins that create
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| | deficiencies visit Micheal Furman MD,
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| an impermeable gasket between the blood
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| | "Spinal Stenosis and Neurogenic
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| and the stomach. Carbon dioxide diffuses
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| | Claudication." E-Medicine, July 21,
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| freely into the cell where it joins with
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| | 2004.2. Tracy G. Anthony, Ali K. Reiter,
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| water. The enzyme carbonic anhydrase,(a
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| | Joshua C. Anthony, Scot R. Kimball, and
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| systemic protein), catalyzes the reaction
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| | Leonard S. Jefferson, " Deficiency of
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| between these two elements, yielding
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| | dietary EAA preferentially inhibits mRNA
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| hydrogen. Chloride ions enter the cell in
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| | translation of ribosomal proteins in
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| a process of ion exchange and on the
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| | liver of meal-fed rats." Am J Physiol
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| stomach side of the cell another large
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| | Endocrinol Metab 281: E430-E439, 2001;
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| protein, H+/K+ Atpase, starts the active
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| | 0193-1849/01, Vol. 281, Issue 3,
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| transport "pump" for HCL production. Free
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| | E430-E439, September 20013. Junction
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| energy (ATP) hydrolyzed by H+/K+ Atpase
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| | Adhesion Molecule 1: Q9Y624, NiceProt
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| pumps out hydrogen (H+) and takes up
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| | View of Swiss-Prot, Uni-Prot Carbonic
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| potassium (K+). K+ flows into the stomach
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| | Anhydrase 1:P00915, Bioinformatic
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| by diffusion through a K+ channel protein
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| | Harvester, Stanford University. Potassium
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| while chloride (CL-) flows into the
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| | Voltage Gated Channel: KCNQ1,
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| stomach through a Cl- channel protein.
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| | Bioinformatic harvester, Stanford
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| This mixture creates a Ph of about .08 in
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| | University Gastric H+/K+ ATPase: P20648,
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| the stomach, which is optimal for food
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| | Bioinformatic Harvester, Stanford
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| digestion. How much of each protein is
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| | University4. Tryptophan
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| EAAs ?:
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| | Hydroxylase:Q86WC5 (fragment),
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| Tight junction protein - 299 total AA
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| | Bioinformatic Harvester, Stanford
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| 151 EAA ( 18% of the EAA being valine)
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| | University Dopa Decarboxolase5. Andrew S.
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| Carbonic Anhydrase - 260 total AA
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| | Chu, MD, "Esophagitis" E-Medicine, Nov.
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| 106 EAA (17 % of the EAA being leucine)
| |
| | 19, 20046. Brabender J, Lord RV,
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| K+ channel protein - 392 total AA
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| | Wickramasinghe K, Metzger R, Schneider
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| 192 EAA ( 16% of the EAA being leucine)
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| | PM, Park JM, Holscher AH, DeMeester TR,
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| H+/K+ Atpase - 1034 total AA
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| | Danenberg KD, Danenberg PV., "Glutathione
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| 500 EAA ( 10% of the EAA being
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| | S-transferase-pi expression is
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| leucine)3Why is there an overproduction
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| | downregulated in patients with Barrett's
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| of acid in the GERD patient? If the
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| | esophagus and esophageal adenocarcinoma."
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| proper essential amino acids must be
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| | Journal of Gastrointestal Surgery. 2002
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| present for the proper function of
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| | May-Jun;6(3):359-67.7. Bounous,J, "Whey
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| proteins, what happens if EAAs are
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| | protein concentrate (WPC) and glutathione
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| missing? Perhaps then the protein
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| | modulation in cancer treatment.",
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| mechanism that makes the HCL for our
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| | Anticancer Res. 2000
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| stomach malfunctions. How do we get these
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| | Nov-Dec;20(6C):4785-92.8. Wang ST, Chen
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| EAAS? By digesting our food
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| | HW, Sheen LY, Lii CK., "Methionine and
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| fully.Serotonin
| |
| | cysteine affect glutathione level,
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| Science is also looking into the role
| |
| | glutathione-related enzyme activities and
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| that the hormone seratonin (5HT) plays in
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| | the expression of glutathione
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| GERD because serotonin mediates the
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| | S-transferase isozymes in rat
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| chemical transfer of information between
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| | hepatocytes." Journal of Nutrition, 1997
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| the brain and gut. It does this via the
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| | Nov;127(11):2135-41.Eve Pekkala is a
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| central nervous system. If the nervous
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| | technical writer for Supernutrient
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| system has been compromised due to
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| | Company. She has a BA in history and has
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| breakdown of the spinal disks, then
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| | studied exercise science at the
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| messages given to the secretory system
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| | University of South Carolina. She has
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| will also be compromised. If the system
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| | been involved in technical writing for
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| does not have adequate amounts of amino
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| | various bodywork and nutritional
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| acids available to build secretory
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| | businesses since 1995.
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